Influencing Factors on Degradation of Penicillin G by Fenton-like Reaction
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Abstract
Penicillin G (PEN G) was discovered and has been used for treating bacterial diseases in humans, animals, and plants. The fact that it contains β-lactam rings is a cause for concern due to its large production and application. Highly common usage in clinical treatment leads to antibiotic resistant bacteria which render medical treatment of the diseases ineffective. PEN G is not degraded during conventional activated sludge processes or adsorption. To eliminate PEN G in the wastewater from a PEN G production facility and the receiving river, influencing factors on PEN G degradation in synthesized wastewater by Fenton-like reaction using calcium peroxide as an oxidant were studied in this work. A High-Performance Liquid Chromatography (HPLC) was used for analyzing PEN G concentration. Experiments were designed by Box-Behnken design (BBD) and conducted in a batch reactor with 150 ppm of initial concentration of PEN G. For the degradation of Penicillin G by Fenton-like reaction, the influencing factors were found to include pH, FeSO4 and CaO2.
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