Assessment of Airborne Microbial Contamination in Cosmetics Manufacturing Facilities: Skincare Cream Production in Thailand
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Abstract
Skincare is a variety of practices to maintain skin integrity, enhance appearance, and alleviating skin conditions. Thailand's skincare market has seen substantial growth, becoming the dominant sub-sector in cosmetics. Microbial contamination in the skincare can occur when the manufacturing process are not well controlled. The objective of this research is to establish criteria for managing appropriate levels of microbial quantities in the air of Good Manufacturing Practice (GMP) cosmetics production facilities. Airborne microbial samples are collected using both active air sampler and settle plate techniques at varying time intervals, followed by a comparative analysis. The skincare creams as representatives showed that the total airborne microbial counts using the air sampling method, ranged from 85 to 252 cfu/m3. For the settle plate method for 4 and 1 hours ranged from 8 to 90 cfu/4h and 1 to 59 cfu/h. The action limits from control charts at 341 cfu/m3, 107 cfu/4h, and 59 cfu/h for the respective methods. Based on the results of this research, it can be concluded that the monitoring criteria for cosmetics manufacturing facilities, with a specified limit for airborne microbial counts not exceeding 100 cfu/4h (sterile medicinal products at Grade D) or 50 cfu/h (moderate IMA level).
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