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Winning business competition is one ultimate goal of most organizations. Many literatures suggest virous strategies to support organizations’ strategy such as competitive advantage, blue ocean, and built to last. This paper uses empirical study to analyze the key success factor of organizations in various industry and found that indispensability is a key success factory. Indispensability is the ability of firm to be undeniable from their customer. In addition, this paper has suggested 1) innovation 2) stay relevant and 3) business connections and merger with the right partner as three main approach toward indispensability.